Role for toll-like receptor 9 in muscle AMPK activation
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چکیده
منابع مشابه
Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells.
Unmethylated CpG motifs present in bacterial DNA stimulate a rapid and robust innate immune response. Human cell lines and PBMC that recognize CpG DNA express membrane-bound human Toll-like receptor 9 (hTLR9). Cells that are not responsive to CpG DNA become responsive when transfected with hTLR9. Expression of hTLR9 dramatically increases uptake of CpG (but not control) DNA into endocytic vesic...
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Toll-like receptor 9 (TLR9) is an innate immune sensor for microbial DNA that erroneously responds to self DNA in autoimmune disease. To prevent autoimmune responses, Toll-like receptor 9 is excluded from the cell surface and silenced until the N-terminal half of the ectodomain (TLR9N) is cleaved off in the endolysosome. Truncated Toll-like receptor 9 (TLR9C) senses ingested microbial DNA, alth...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2020
ISSN: 1759-5029,1759-5037
DOI: 10.1038/s41574-020-0337-9